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They don’t get a pleasant feeling
Tickling produces a pleasant response in ticklish people, and as a result, they laugh. Some people have nerves that don’t produce that pleasant response, and as a result, they are not ticklish. In such a case, those people might feel uncomfortable when tickled.
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Lower sensitivity to touching
A person’s response to tickling will depend on his sensitivity to touching. Lower sensitivity to touching might prevent a person from being ticklish.
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They were not conditioned to tickling
Some scientists believe that being ticklish is a conditioned response. According to this theory, a person must first learn to respond to tickling with laughter to respond later on in the same way. Some people could not have been conditioned to tickling.
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You are not touching the right areas
Some people might be ticklish, but for the right response to happen, the proper area must be reached. In such a case, touching the wrong area might not lead to a laughter response.
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Less sensitive nervous system
The laughter response is believed to be a reflex made by the nervous system. If a person’s nervous system is less sensitive, then this person might not be that ticklish. (See 20 Signs That You Are Emotionally Sensitive)
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They aged fast
As people age, their touch receptors get reduced. Older people are thus less likely to be ticklish than younger people.
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They formed a different bonding instinct
According to some experts, the ticklish response might be associated with the child’s bonding instincts at an early age. This bonding style might determine how a person responds to touching later on.
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Lower anxiety response
Some people suggest that tickling results in fear response and that the purpose of that response is to help a person defend himself from attackers. According to this theory, the less the anxiety response of a person, the less likely he is to tickle. (See The Body Language of Anxiety)